A fully validated GC-TOF-MS method for the quantification of fatty acids revealed alterations in the metabolic profile of fatty acids after smoking cessation
A diet-controlled clinical smoking cessation study was conducted. A GC-TOF-MS metabolic profiling method for fatty acids has been developed. A comprehensive validation of the GC-TOF-MS method according to FDA guidelines was conducted. Statistical significant alterations during smoking cessation indicate a partial recovery of the fatty acid metabolism.