NFAT1 promotes cell motility through MMP-3 in esophageal squamous cell carcinoma

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• 作者：Peinan Chen^a ; ^b ; Zhengzheng Shan^c ; Jianbo Zhao^d ; Fengke Li^a ; Wenqiang Zhang^a ; Liankai Yang^a ; Zhuangshi Huang^a ; ^{chest@163.com}
• 关键词：Esophageal squamous cell carcinoma (ESCC) ; Nuclear factor of activated t cell (NFAT1) ; MMP-3
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：86
• 期：Complete
• 页码：541-546
• 全文大小：2032 K
• 卷排序：86

文摘

Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors and the prognosis of patients remains poor. Increasing evidence suggests that nuclear factor of activated T cell (NFAT1) plays an important role in the development and progression of cancers. Herein, we show that NFAT1 was overexpressed in human ESCC, which was significantly associated with advanced tumor stage and lymph node metastasis. Functional studies found that NFAT1 silencing could suppress cell migration and invasion through MMP-3. The data therefore suggest that NFAT1 plays an important adverse role in the development and progression of ESCC, implicating possible application in clinics as a biomarker and a potential new therapeutic target.