Cocaine self-administration, extinction training and drug-induced relapse change metabotropic glutamate mGlu5 receptors expression: Evidence from radioligand binding and immunohistochemistry assays

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• 作者：Lucyna Pomierny-Chamiolo^a ; ^{lpomiern@cm-uj.krakow.pl} ; Joanna Miszkiel^b ; Malgorzata Frankowska^b ; Beata Bystrowska^a ; Malgorzata Filip^b
• 关键词：Cocaine self-administration ; Extinction training ; Drug-induced relapse ; MGlu5 receptor binding ; MGlu5 receptor immunohistochemistry
• 刊名：Brain Research
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：1655
• 期：Complete
• 页码：66-76
• 全文大小：1660 K
• 卷排序：1655

文摘

Cocaine self-administration alters [3H]MPEP binding to mGlu5 receptors in brain structures. Extinction training from cocaine leads to bi-phasic changes in mGlu5 receptors density in brain areas. Cocaine priming dose alters mGlu5 receptors density and [3H]MPEP affinity in the hippocampus.