Nicotine stabilization in composite sodium alginate based wafers and films for nicotine replacement therapy
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- 作者：Obinna C. Okeke ; Joshua S. Boateng ; J.S.Boateng@gre.ac.uk" class="auth_mail" title="E-mail the corresponding author ; joshboat40@gmail.com" class="auth_mail" title="E-mail the corresponding author ; joshboat@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Gelatine ; Glycerol ; Hydroxypropylmethylcellulose ; Magnessium aluminium silicate ; Mucin ; Nicotine ; Potassium dihydrogen phosphate ; Sodium acetate ; Sodium alginate ; Trimethylamine
- 刊名：Carbohydrate Polymers
- 出版年：2017
- 出版时间：2 January 2017
- 年：2017
- 卷：155
- 期：Complete
- 页码：78-88
- 全文大小：1838 K
文摘
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Nicotine has been loaded into composite sodium alginate based films and wafers for nicotine replacement therapy (NRT).
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Magnesium aluminium silicate and sodium alginate helped stabilise the nicotine within the formulations and enhanced drug recovery.
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The films and wafers showed different physical properties which affected their functional characteristics for an ideal buccal NRT.