Acute restraint stress induces specific changes in nitric oxide production and inflammatory markers in the rat hippocampus and striatum
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- 作者：Hsiao-Jou Cortina Chen ; Jereme G. Spiers ; j.spiers@uq.edu.au" class="auth_mail" title="E-mail the corresponding author ; Conrad Sernia ; Nickolas A. Lavidis
- 关键词：CIITA ; class II major histocompatibility complex transactivator ; GR ; glucocorticoid receptor ; MIF ; macrophage migration inhibitory factor ; sGC ; soluble guanylyl cyclase
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：90
- 期：Complete
- 页码：219-229
- 全文大小：3317 K
文摘
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Acute stress induces shift from constitutive to iNOS signaling in hippocampus.
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Acute stress induces rapid down-regulation of hippocampal nNOS mRNA expression.
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Striatal NO following acute stress is predominately iNOS-mediated.
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Profile of pro-inflammatory responses differ in hippocampus and striatum.
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Hippocampal iNOS and cytokine response indicate switch to adaptive immunity.