Astrocyte Depletion Impairs Redox Homeostasis and Triggers Neuronal Loss in the Adult CNS
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- 作者：Bettina Schreiner1 ; 2 ; Elisa Romanelli3 ; Pawel Liberski4 ; Barbara Ingold-Heppner5 ; Bettina Sobottka-Brillout1 ; 6 ; Tom Hartwig1 ; Vijay Chandrasekar7 ; Helge Johannssen8 ; Hanns Ulrich Zeilhofer8 ; 9 ; Adriano Aguzzi7 ; Frank Heppner10 ; Martin Kerschensteiner3 ; 11 ; Burkhard Becher1 ; becher@immunology.uzh.ch" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：1 September 2015
- 年：2015
- 卷：12
- 期：9
- 页码：1377-1384
- 全文大小：2116 K
文摘
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When adult GFAP+ astrocytes are depleted in vivo, motor skills are severely impaired
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Neuronal loss occurs, whereas astroglial structural support still persists
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Astroglial dysfunction disrupts CNS redox homeostasis, independent of microgliosis
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Neutralization of ROS/RNS protects from neuronal injury