Effects of tianeptine on the development and maintenance of mechanical allodynia in a rat model of neuropathic pain
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- 作者：Bong Ha Heo ; Jae Yun Shin ; Keun Suk Park ; Hyung Gon Lee ; Jeong Il Choi ; Myung Ha Yoon ; Woong Mo Kim ; M.D. ; Ph.D ; kimwm@jnu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tianeptine ; Neuropathic pain ; Allodynia ; Rat model
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：28 October 2016
- 年：2016
- 卷：633
- 期：Complete
- 页码：82-86
- 全文大小：911 K
文摘
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Preemptive intrathecal administration of tianeptine significantly increased the paw withdrawal threshold after SNL.
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However, intraperitoneal pretreatment did not significantly increased the paw withdrawal threshold after SNL.
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Nevertheless, intraperitoneal tianeptine potentiated the antiallodynic effects of subsequently administered tianeptine.