Chemical stimulation of the intracranial dura activates NALP3 inflammasome in trigeminal ganglia neurons
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- 作者：Lingzhi Chena ; Xiaohui Lia ; Lin Huanga ; Qian Wua ; Ling Chenb ; Qi Wana ; qi_wan@126.com" class="auth_mail
- 关键词：CGRP ; calcitonin gene-related peptide ; DMSO ; dimethyl sulfoxide ; GFAP ; glia fibrillary acidic protein ; IS ; inflammatory soup ; IL-1尾 ; interleukin (IL)-1尾 ; NALP3 ; NACHT ; LRR and PYD-containing protein (NALP)-3 ; PAN ; primary afferent neuron ; SGC ; satellite glial cell ; TG ; trigeminal ganglia
- 刊名：Brain Research
- 出版年：30 May 2014
- 年：2014
- 卷：1566
- 期：Complete
- 页码：1-11
- 全文大小：2430 K
文摘
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We use chemical stimulation of the rat’s dura as a model of intracranial pain.
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Dural inflammation promoted assembly of the multiprotein NALP3 complex in TG neurons.
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Dural inflammation induces processing of proIL-1尾 into the actived form in TG neurons.
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Caspase-1 inhibition reduces IS-induced activation and processing of IL-1尾.
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The NALP3 inflammasome and IL-1尾 are present mainly in C-type neurons of TGs.