WNT/β-catenin signaling promotes VSMCs to osteogenic transdifferentiation and calcification through directly modulating Runx2 gene expression
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- 作者：Ting Cai1 ; Danqin Sun1 ; Ying Duan ; Ping Wen ; Chunsun Dai ; Junwei Yang ; jwyang@njmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Weichun He ; heweichun@njmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：VSMCs ; vascular smooth muscle cells ; AMC ; arterial medial calcification ; β-GP ; β-glycerophosphoricacid ; LRP ; low density lipoprotein receptor-related protein ; GSK ; glycogen synthase kinase ; PORCN ; Porcupine
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：345
- 期：2
- 页码：206-217
- 全文大小：2396 K
文摘
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High-phosphate induces Runx2 expression in VSMCs through activating β-catenin.
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Two forms of active β-catenin are upregulated in VSMCs treated with high-phosphate.
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Two functional TBEs are identified in the promoter region of Runx2 gene in VSMCs.
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Targeting WNT/β-catenin signaling may offer therapeutic intervention for AMC.
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