A Role for SIRT1 in the Hypoxic Response

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• 作者：Scott F. Leiser ; Matt Kaeberlein
• 刊名：Molecular Cell
• 出版年：2010
• 出版时间：25 June 2010
• 年：2010
• 卷：38
• 期：6
• 页码：779-780
• 全文大小：112 K

文摘

In this issue of Molecular Cell, Lim et al. (2010) show that SIRT1 deacetylates HIF-1α and regulates its ability to respond to hypoxia, revealing yet another important function of SIRT1 and suggesting a connection between HIF function in aging and sirtuin enzymes.