The mitochondrial unfolded protein response and increased longevity: Cause, consequence, or correlation?
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- 作者：Christopher F. Bennetta ; b ; Matt Kaeberleina ; kaeber@uw.edu" class="auth_mail
- 关键词：Mitochondrial unfolded protein response ; C. elegans ; ATFS-1 ; Prohibitins ; HSP-6
- 刊名：Experimental Gerontology
- 出版年：August 2014
- 年：2014
- 卷：56
- 期：Complete
- 页码：142-146
- 全文大小：277 K
文摘
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The UPRmt is a conserved response to mitochondrial stress.
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Several perturbations that induce the UPRmt extend lifespan in C. elegans.
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In some cases, the UPRmt is associated with shortened or normal lifespan.
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The UPRmt is proposed to promote longevity in C. elegans.
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Key experimental support of the UPRmt longevity model is lacking.
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