Quantification of bone marrow water and lipid composition in anterior cruciate ligament-injured and osteoarthritic knees using three-dimensional magnetic resonance spectroscopic imaging

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• 作者：Lauren S. Tufts ^{LST2003@med.cornell.edu" class="auth_mail" title="E-mail the corresponding author} ; Keerthi Shet ^{Shet.Keerthi@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Fei Liang ^{FY.Liang1@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Sharmila Majumdar ^{Sharmila.Majumdar@ucsf.edu" class="auth_mail" title="E-mail the corresponding author} ; Xiaojuan Li ; ^{Xiaojuan.Li@ucsf.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：OA ; osteoarthritis ; BMEL ; bone marrow edema-like lesion ; MR ; magnetic resonance ; MRS ; MR spectroscopy ; MRSI ; MR spectroscopic imaging ; ACL ; anterior cruciate ligament ; 3D ; three-dimensional ; FSE ; fast spin-echo ; PRESS ; point-resolved spectral-selection ; VOI ; volume of interest ; ms ; millisecond ; WC ; water content ; UI ; lipid unsaturation index
• 刊名：Magnetic Resonance Imaging
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：34
• 期：5
• 页码：632-637
• 全文大小：681 K

文摘

To quantitatively evaluate longitudinal changes in water and lipid in knee bone marrow with and without bone marrow edema-like lesions (BMELs) in subjects with acutely ruptured anterior cruciate ligaments (ACLs) or osteoarthritis (OA) using three-dimensional magnetic resonance spectroscopic imaging (3D MRSI).

Material and methods

Ten ACL and 10 OA subjects who presented with BMEL and seven BMEL-free controls were scanned at 3 T. All ACL and OA subjects had one-year follow-up scans. 3D MRSI was acquired in BMEL and adjacent bone marrow, and water content (WC) and unsaturated lipid index (UI) were calculated in each region of interest.

Results

At baseline, ACL BMEL WC was significantly higher than ACL non-BMEL, OA BMEL, and control WC; ACL non-BMEL WC, ACL BMEL UI, and OA BMEL WC were significantly higher than control. ACL BMEL WC decreased significantly one year post-reconstruction; UI decreased non-significantly (p = 0.09). No significant changes in OA BMEL or ACL and OA non-BMEL WC and UI were observed.

Conclusion

3D MRSI is a powerful method of quantitatively assessing the biochemical composition of bone marrow in OA and ACL-injured knees, which may serve as imaging markers to improve comprehension of primary and secondary OA pathology.