ω-3 polyunsaturated fatty acid supplementation ameliorates lipopolysaccharide-induced behavioral deficits and modulates neurotrophic factors in rats: Focus on tPA/PAI-1 system and BDNF-TrkB signaling

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• 作者：Ruili Dang^a ; ¹ ; Xueyuan Zhou^b ; ¹ ; Pengfei Xu^a ; Yujin Guo^a ; Xiaoxue Gong^a ; Shan Wang^a ; Fang Yuan^a ; Jia Yao^a ; Pei Jiang^a ; ^{jiangpeicsu@sina.com}
• 关键词：BDNF ; brain-derived neurotrophic factor ; LPS ; lipopolysaccharide ; NGF ; nerve growth factor ; PAI-1 ; plasminogen activator inhibitor-1 ; PUFA ; polyunsaturated fatty acid ; tPA ; tissue plasmogen activator ; SSRI ; selective serotonin reuptake inhibitor ; TrkB ; tropomyosin receptor kinase B ; VEGF ; vascular endothelial growth factor
• 刊名：Journal of Functional Foods
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：30
• 期：Complete
• 页码：74-80
• 全文大小：1684 K
• 卷排序：30

文摘

LPS exposure induced depression-like behaviors in rats. LPS exposure altered tPA/PAI-1 system and attenuated proBDNF cleavage into mBDNF. LPS exposure compromised TrkB activation. PUFA treatment restored altered tPA/PAI-1 system and BDNF-TrkB activation.