ASH1L Suppresses Matrix Metalloproteinase through Mitogen-activated Protein Kinase Signaling Pathway in Pulpitis

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• 作者：Yin Bei ; MD ; Hui Tianqian ; MD ; Yu Fanyuan ; BD ; Luo Haiyun ; PhD ; Liao Xueyang ; MD ; Yang Jing ; PhD ; Wang Chenglin ; PhD ; Ye Ling ; PhD ; ^{ling-ye@hotmail.com}
• 关键词：ASH1L ; epigenetic ; matrix metalloproteinase ; pulpitis
• 刊名：Journal of Endodontics
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：43
• 期：2
• 页码：306-314.e2
• 全文大小：1945 K
• 卷排序：43

文摘

Our research highlights a mechanism by which ASH1L suppresses matrix metalloproteinase expression and activity during pulpitis through the mitogen-activated protein kinase pathway. TNF-α treatment induced the expression of ASH1L through the nuclear factor kappa B and MAPK signal pathways. ASH1L was found in increased quantities in experimental dental pulpitis tissue.