Characterization of chlorophyll derivatives in micelles of polymeric surfactants aiming photodynamic applications

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• 作者：Adriana Passarella Gerola^a ; Flavia Amanda Pedroso de Morais^a ; Paulo Fernando A. Costa^a ; Elza Kimura^b ; Wilker Caetano^a ; Noboru Hioka^a ; ^{nhioka@uem.br}
• 关键词：Chlorophylls ; Polymeric micelles ; Formulation ; Drug delivery system
• 刊名：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：173
• 期：Complete
• 页码：213-221
• 全文大小：715 K
• 卷排序：173

文摘

Hydrophobic chlorophylls (Chls) were formulated and monomerized in P-123 and F-127 micelles. Chlorophylls with phytyl chain were localized in the micelle's core while phorbides are positioned in the outer layer. The presence of chlorophylls resulted in stable formulations even at low temperatures. The microenvironment of the P-123/Chls presents lesser temperature-dependence than F-127 micelles. The results help us to design a new drug delivery system for chlorophylls based on pluronics aqueous micelles.