A decrease in cellular microRNA-27a content is involved in azacytidine-induced P-glycoprotein expression in SKM-1 cells
详细信息 查看全文
- 作者：Lucia Messingerovaa ; b ; Denisa Imrichovab ; Helena Kavcovab ; Mario Seresb ; Zdena Sulovab ; zdena.sulova@savba.sk" class="auth_mail" title="E-mail the corresponding author ; Albert Breiera ; b ; albert.breier@stuba.sk" class="auth_mail" title="E-mail the corresponding author
- 关键词：AML cell line SKM-1 ; P-glycoprotein ; miRNA-27a ; NF-κB ; Multidrug resistance ; Azacytidine
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：36
- 期：Complete
- 页码：81-88
- 全文大小：904 K
文摘
- •
MDR SKM-1/AzaC cell variant by long-term passaging with AzaC was established.
- •
Massive overexpression of P-gp in SKM-1/AzaC cells was observed.
- •
Downregulation of miRNA-27a in SKM-1/AzaC cells was detected.
- •
Downregulation of P-gp by transfection of these cells with miRNA-27a was observed.