A novel paper-supported aptasensor based on luminescence resonance energy transfer from upconversion nanoparticles to carbon nanoparticles was developed.
Carbon nanoparticles were used as energy acceptor for paper-based LRET assays for the first time.
The method was applicable in serum samples for total IgE detection.
The results were well correlated to those obtained from chemiluminescence-based clinical assay.