Nervous necrosis virus capsid protein exploits nucleolar phosphoprotein Nucleophosmin (B23) function for viral replication

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• 作者：Weijun Mai ; ^{mwj9876@mail.ujs.edu.cn} ; Fang Huang ; Huiqing Chen ; Yajing Zhou ; Yan Chen
• 关键词：Nervous necrosis virus ; Capsid protein ; Nucleolar protein B23 ; Interaction ; Viral replication
• 刊名：Virus Research
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：230
• 期：Complete
• 页码：1-6
• 全文大小：1171 K
• 卷排序：230

文摘

An interaction between nervous necrosis virus capsid protein and nucleolar phosphoprotein B23 was identified. The capsid protein binds to B23 early during the viral infection and accumulates in the nucleolus. Knockdown of B23 reduces the cytopathic effect (CPE) and replication efficiency of NVV. The interaction of B23 with NNV capsid protein may represent an important mechanism in NNV replication.