Morphometric alterations of Golgi apparatus in Alzheimer's disease are related to tau hyperphosphorylation

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• 作者：Alejandro Antó ; n-Ferná ; ndez^a ; ^b ; Guillermo Aparicio-Torres^a ; ^b ; Silvia Tapia^a ; ^b ; Javier DeFelipe^a ; ^b ; ^c ; Alberto Muñ ; oz^a ; ^b ; ^d ; ^{amunozc@bio.ucm.es}
• 关键词：Taupathy ; Dementia ; Human hippocampus ; Human neocortex ; Microtubules ; Neurofibrillary tangles
• 刊名：Neurobiology of Disease
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：97
• 期：part_PA
• 页码：11-23
• 全文大小：5612 K
• 卷排序：97

文摘

The Golgi apparatus of cortical neurons is affected in Alzheimer's disease patients. Golgi apparatus alterations include fragmentation and a decrease in size. Phospho-tau accumulation in neurons is correlated with Golgi apparatus alterations.