Developmental manganese exposure in combination with developmental stress and iron deficiency: Effects on behavior and monoamines
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- 作者：Robyn M. Amos-Kroohsa ; b ; Laurie L. Davenportc ; Arnold Gutierreza ; b ; Jillian R. Hufgarda ; b ; Charles V. Vorheesa ; b ; Michael T. Williamsa ; b ; michael.williams@cchmc.org" class="auth_mail" title="E-mail the corresponding author ; charles.vorhees@cchmc.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Manganese ; Iron deficiency ; Barren cage ; Development ; Behavior ; Neurotransmitters
- 刊名：Neurotoxicology and Teratology
- 出版年：2016
- 出版时间：July-August 2016
- 年：2016
- 卷：56
- 期：Complete
- 页码：55-67
- 全文大小：1868 K
文摘
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Mn overexposure (MnOE) P4-, iron deficiency (FeD) E15-, barren cage (BAR) E7-P28
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MnOE decreased open-field activity, ASR, social preference and novelty.
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BAR decreased growth, anxiety, PPI, sucrose preference and increased ASR.
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FeD decreased growth and tapered beam performance.
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MnOE altered monoamines, mostly dopamine in different regions.