Theophylline as a new and green catalyst for the one-pot synthesis of spiro[benzo[a]pyrano[2,3-c]phenazine] and benzo[a]pyrano[2,3-c]phenazine derivatives under solvent-free conditions

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• 作者：Afshin Yazdani-Elah-Abadi^a ; Malek-Taher Maghsoodlou^a ; ^{mt_maghsoodlou@yahoo.com} ; ^{mt_maghsoodlou@chem.usb.ac.ir} ; Razieh Mohebat^b ; Reza Heydari^a
• 关键词：Multi-component domino reactions (MDRs) ; Green chemistry ; Theophylline ; Spiro[benzo[a]pyrano[2 ; 3-c]phenazine] ; Benzo[a]pyrano[2 ; 3-c]phenazine
• 刊名：Chinese Chemical Letters
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：28
• 期：2
• 页码：446-452
• 全文大小：874 K
• 卷排序：28

文摘

A green, convenient, high yielding and one-pot procedure for the synthesis of novel spiro[benzo[a]pyrano[2,3-c]phenazine] derivatives by domino multi-component condensation reaction between 2-hydroxynaphthalene-1,4-dione, benzene-1,2-diamines, ninhydrine, and malononitrile in the presence of a catalytic amount of 1,3-dimethyl-7H-purine-2,6-dione (theophylline) as an expedient, eco-friendly and reusable solid base catalyst under thermal, microwave irradiation and solvent-free conditions. This procedure has also been applied successfully for the synthesis of benzo[a]pyrano[2,3-c]phenazines.