Therapeutic potential of hepcidin − the master regulator of iron metabolism

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• 作者：Daniel Vyoral^a ; ^b ; ^{vyoral@uhkt.cz} ; Jiri Petrak^c ; ^a
• 关键词：Iron ; Iron therapy ; Hepcidin ; Anemia of chronic disease ; Iron deficiency anemia ; Thalassemia ; Hemochromatosis ; Iron overload
• 刊名：Pharmacological Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：115
• 期：Complete
• 页码：242-254
• 全文大小：2030 K
• 卷排序：115

文摘

Iron is an essential biogenic element for both prokaryotic and eukaryotic cells. In humans iron is present in hundreds of different metalloproteins. The peptide hormone hepcidin serves as a master regulator of iron homeostasis on the level of single cells and whole organism − by altering cell surface expression of cellular iron exporter − protein ferroportin. Altered levels of extracellular hepcidin lead to pathological conditions such as hemochromatosis and iron loading or, on the other side, iron restrictive anemias. Therapeutic modulation of hepcidin is a new and promising approach to treatment of these conditions. In this review, a summary of the current knowledge of hepcidin function, regulation and pathological involvements are provided, followed by a section covering the therapeutic potential of hepcidin and the current strategies how to modulate its levels and biological functions for therapeutic purposes.