Two Independent Pathways within Selective Autophagy Converge to Activate Atg1 Kinase at the Vacuole
详细信息 查看全文
- 作者：Raffaela Torggler1 ; 2 ; Daniel Papinski1 ; 2 ; Thorsten Brach1 ; 2 ; Levent Bas1 ; Martina Schuschnig1 ; Thaddä ; us Pfaffenwimmer1 ; Sabrina Rohringer1 ; Tamara Matzhold1 ; David Schweida1 ; Andrea Brezovich1 ; Claudine Kraft1 ; 3 ; claudine.kraft@univie.ac.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：Atg1-ULK1 kinase ; autophagy ; Cvt pathway ; pexophagy ; Atg11 ; Atg19 ; Atg36 ; Atg13 ; iPass
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：20 October 2016
- 年：2016
- 卷：64
- 期：2
- 页码：221-235
- 全文大小：3215 K
文摘
- •
Atg1 activation in selective autophagy is tightly regulated in space and time
- •
Atg1 is activated by the convergence of two independent pathways at the vacuole
- •
Cargo receptors and Atg13 function as tethers for Atg11 and Atg1, respectively
- •
Both cargo receptors and Atg13 can be functionally bypassed in selective autophagy