Wildtype and Npas4 knockout mice were compared in behavioural and cognitive tests following photochemically-induced stroke.
Spatial recognition memory is impaired in Npas4−/− and wildtype mice after stroke.
Despair-like behaviour is reduced in both Npas4−/− and wildtype mice after stroke.
Stroke leads to increased anxiety in Npas4−/− mice but not wildtype mice.
Stroke leads to decreased sociability in wildtype mice but not in Npas4−/− mice.