CB1 cannabinoid receptor-mediated anandamide signalling reduces the defensive behaviour evoked through GABAA receptor blockade in the dorsomedial division of the ventromedial hypothalamus
Administration of bicuculline intra-VMHdm induced panic-like responses. Anandamide attenuated defence responses induced by bicuculline. Anandamide modulates the pro-aversive effects of bicuculline, recruiting CB1 receptors. AM251 potentiated the non-oriented escape induced by bicuculline. AM251-induced potentiation of bicuculline effect is related to TRPV1 vanilloid receptor activity.