Synthesis of spiroindene-1,3-dione isothiazolines via a cascade michael/1,3-dipolar cycloaddition reaction of 1,3,4-oxathiazol-2-one and 2-arylidene-1,3-indandiones

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• 作者：Anjaiah Aitha^a ; ^b ; Satyanarayana Yennam^a ; ^{satya@gvkbio.com} ; Manoranjan Behera^a ; Jaya Shree Anireddy^b
• 关键词：1 ; 3-Dipolar cycloaddition ; 1 ; 3 ; 4-Oxathizole-2-one ; Indanedione ; Isothiazoline ; Regioisomers
• 刊名：Tetrahedron Letters
• 出版年：2017
• 出版时间：8 February 2017
• 年：2017
• 卷：58
• 期：6
• 页码：578-581
• 全文大小：499 K
• 卷排序：58

文摘

Novel spiroindene-1,3-dione isothiazoline derivatives were synthesized. Michael/1,3-dipolar [3+2]-cycloaddition reaction was investigated using 1,3,4-oxathiazol-2-one moiety. Two regioisomers of spiroindene-1,3-dione isothiazoline was separated. The regioisomer 18a was successfully separated into its two enantiomers.