Bilobalide abates inflammation, insulin resistance and secretion of angiogenic factors induced by hypoxia in 3T3-L1 adipocytes by controlling NF-κB and JNK activation

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• 作者：A Priyanka ; G Sindhu ; GL Shyni ; MR Preetha Rani ; VM Nisha ; KG Raghu ; ^{raghukgopal@niist.res.in}
• 关键词：Hypoxia ; Inflammation ; Insulin resistance ; 3T3-L1 adipocytes ; Bilobalide
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：42
• 期：Complete
• 页码：209-217
• 全文大小：1074 K
• 卷排序：42

文摘

Hypoxia induces the secretion of inflammatory cytokines in 3T3-L1 adipocytes. Upregulation of cytokines leads to activation of JNK and NF-κB signalling. Inhibitory phosphorylation of IRS-1 by JNK and NF-κB activation induces insulin resistance. Hypoxia also induces release of angiogenic factors. Bilobalide dose dependently protect hypoxia induced inflammation and insulin resistance.