Virus replication kinetics and pathogenesis of infection with H7N9 influenza virus in isogenic guinea pigs upon intratracheal inoculation
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- 作者：Lidewij C.M. Wiersmaa ; Joost H.C.M. Kreijtza ; Stella E. Vogelzang-van Trieruma ; Geert van Amerongena ; b ; Peter van Runa ; Mechtild Ladwigc ; Stefanie Bannekec ; Hubert Schaeferd ; Ron A.M. Fouchiera ; Thijs Kuikena ; Albert D.M.E. Osterhausa ; b ; Guus F. Rimmelzwaana ; b ; g.rimmelzwaan@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：H7N9 ; Isogenic guinea pig ; Pathogenesis ; Animal model ; Influenza
- 刊名：Vaccine
- 出版年：2015
- 出版时间：8 December 2015
- 年：2015
- 卷：33
- 期：49
- 页码：6983-6987
- 全文大小：2036 K
文摘
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Guinea pigs are susceptible to unadapted human and avian influenza viruses.
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Influenza A/H7N9 virus is an avian virus first isolated from humans in 2013.
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A/H7N9 virus replicated to high titers in the entire respiratory tract of guinea pigs.
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Infection caused rhinitis, tracheitis and bronchointerstitial pneumonia.
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Peak of viral excretion was at day 2 and continued until 7 days post-inoculation.