Tyrosine Detoxification Is an Essential Trait in the Life History of Blood-Feeding Arthropods
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- 作者：Marcos Sterkel1 ; msterkel29@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Hugo D. Perdomo1 ; Melina G. Guizzo1 ; Ana Beatriz F. Barletta1 ; Rodrigo D. Nunes1 ; Felipe A. Dias1 ; Marcos H.F. Sorgine1 ; 2 ; Pedro L. Oliveira1 ; 2 ; pedro@bioqmed.ufrj.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：tyrosine metabolism ; HPPD inhibitors ; hematophagous vectors ; neglected diseases
- 刊名：Current Biology
- 出版年：2016
- 出版时间：22 August 2016
- 年：2016
- 卷：26
- 期：16
- 页码：2188-2193
- 全文大小：1753 K
文摘
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Blood-sucking insects ingest blood meals several-fold their weight before feeding
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Toxic concentrations of tyrosine are produced by blood digestion
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Capacity to detoxify excess tyrosine is an essential life trait for these animals
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Inhibition of tyrosine degradation selectively kills blood-sucking arthropods