Optimization of hyaluronan-based eye drop formulations
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- 作者：Rosanna Salzillo ; Chiara Schiraldi ; chiara.schiraldi@unina2.it" class="auth_mail" title="E-mail the corresponding author ; Luisana Corsuto ; Antonella D&rsquo ; Agostino ; Rosanna Filosa ; Mario De Rosa ; Annalisa La Gatta ; annalisa.lagatta@unina2.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hyaluronan ; Eye drops ; Viscosity ; Mucoadhesiveness ; Corneal epithelial cells
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：20 November 2016
- 年：2016
- 卷：153
- 期：Complete
- 页码：275-283
- 全文大小：1697 K
文摘
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Hydrodynamic and rheological evaluations of HA-based eye drops were achieved.
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Most of commercial HA-based eye drops are not optimized.
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Combinations of HA molecular weight/amount maximizing performance were determined.
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Formulations expected to have maximized retention on ocular surface were developed.
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Developed formulas show improved protection of corneal epithelium from dehydration.