A label-free ultrasensitive assay of 8-hydroxy-2′-deoxyguanosine in human serum and urine samples via polyaniline deposition and tetrahedral DNA nanostructure
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- 作者：Jiahui Fan1 ; Yuanjian Liu1 ; Ensheng Xu ; Yuanjian Zhang ; Wei Wei ; weiw@seu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Lihong Yin ; Yuepu Pu ; Songqin Liu
- 关键词：8-OHdG ; Hemin/G-quadruplex ; Tetrahedral DNA nanostructure ; Polyaniline ; Electrochemistry
- 刊名：Analytica Chimica Acta
- 出版年：2016
- 出版时间：23 November 2016
- 年：2016
- 卷：946
- 期：Complete
- 页码：48-55
- 全文大小：1174 K
文摘
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The method for detection of 8-OHdG is label free.
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High activity of hemin/G-quadruplex was induced by 8-OHdG.
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Both TDN and hemin/G-quadruplex were good template for PANI deposition.
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The sensitivity was improved to almost 300-fold compared with reported EC methods.
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The method has been applied in urine and serum samples with satisfactory results.