Investigation of sulfonamides inhibition of carbonic anhydrase enzyme using multiphotometric and electrochemical techniques
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- 作者：Ilhame Bourais ; Sara Maliki ; Hasna Mohammadi ; Aziz Amine ; azizamine@yahoo.fr" class="auth_mail" title="E-mail the corresponding author ; a.amine@univh2m.ac.ma" class="auth_mail" title="E-mail the corresponding author
- 关键词：Sulfonamides ; Multiphotometric assay ; Carbonic anhydrase ; Electrochemical biosensor ; Enzyme inhibition
- 刊名：Enzyme and Microbial Technology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：96
- 期：Complete
- 页码：23-29
- 全文大小：1032 K
文摘
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Novel method based on the achievement of high-throughput using multi well plates for sulfonamides screening was investigated.
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Novel electrochemical carbonic anhydrase inhibition biosensor for sulfanilamide determination was developed.
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CA inhibition mechanism was noncompetitive for sulfanilamide.
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Interference study demonstrated very good selectivity towards sulfanilamide.