Furanoditerpenes from Arcangelisia flava (L.) Merr. and their antifungal activity

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• 作者：Toshisada  ; Suzuki^a ;   ; ^{t-suzuki@ag.kagawa-u.ac.jp} ; Tamiko  ; Kiyotani^b ; Mami  ; Maeda^a ; Takeshi  ; Katayama^a ; Kaori  ; Tomita-Yokotani^c ; Wasrin  ; Syafii^d ; Sipon  ; Muladi^e
• 关键词：Akar kuning ; Arcangelisia flava (L.) Merr. ; Antifungal activity ; Furanoditerpene ; NMR X-ray crystallographic analysis
• 刊名：Phytochemistry Letters
• 出版年：2011
• 出版时间：September 2011
• 年：2011
• 卷：4
• 期：3
• 页码：333-336
• 全文大小：328 K

文摘

Two furanoditerpenes, 2¦Á,3¦Á-epoxy-2,3,7,8¦Á-tetrahydropenianthic acid methyl ester (1) and 2¦Á,3¦Á-epoxy-2,3-dihydropenianthic acid methyl ester (2) were isolated and identified from the root of Arcangelisia flava (L.) Merr. The configuration of 1 was determined by X-ray crystallographic analysis and two-dimensional NMR. Fibraurin (3), fibleucin (4), 2¦Â, 3¦Á-dihydroxy-2,3,7,8¦Á-tetrahydropenianthic acid-2,17-lactone (5), p-hydroxybenzaldehyde and vanillin were also isolated and identified by NMR and EI-MS or FAB-MS. The 2¦Â, 3¦Á-dihydroxy-2,3,7,8¦Á-tetrahydropenianthic acid-2,17-lactone (5) showed the highest antifungal activity of the isolated five furanoditerpenes against a white-rot fungus (Trametes versicolor) and a brown-rot fungus (Fomitopsis palustris).