Thyroglobulin antibodies as a potential predictive marker of papillary thyroid carcinoma in patients with indeterminate cytology
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- 作者：Theodore Karatzas ; Ph.D.a ; 1 ; Ioannis Vasileiadis ; M.D.b ; c ; 1 ; j.vasileiadis@yahoo.gr" class="auth_mail" title="E-mail the corresponding author ; Evangelia Zapanti ; Ph.D.d ; Georgios Charitoudis ; Ph.D.b ; Efthimios Karakostas ; M.D.b ; Georgios Boutzios ; Ph.D.e
- 关键词：Indeterminate cytology ; Thyroid nodules ; Thyroglobulin antibody ; Papillary thyroid carcinoma ; Predictive marker ; Thyroidectomy
- 刊名：The American Journal of Surgery
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：212
- 期：5
- 页码：946-952
- 全文大小：178 K
文摘
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We investigated the efficacy of thyroglobulin antibodies (TgAb) in detecting malignancy.
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This retrospective study included 1646 patients who had undergone preoperative FNAB.
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Multifocality (P = .002), bilaterality (P = .003), lymph-node metastasis (P = .030), and capsule penetration (P = .003) were significantly associated with positive TgAb in papillary thyroid carcinoma (PTC) patients.
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TgAb positivity (P <.001) and preoperative TSH levels (P = .022) were independent predictive factor for PTC.
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Preoperative TgAb could be a marker for PTC in patients with indeterminate thyroid nodules.