Deoxycholic acid transformations catalyzed by selected filamentous fungi
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- 作者：V.V. Kollerova ; T.G. Lobastovaa ; D. Montib ; daniela.monti@icrm.cnr.it" class="auth_mail" title="E-mail the corresponding author ; N.O. Deshcherevskayaa ; E.E. Ferrandib ; G. Fronzac ; S. Rivab ; M.V. Donovaa ; donova@ibpm.pushchino.ru" class="auth_mail" title="E-mail the corresponding author
- 关键词：BA ; bile acid ; DCA ; deoxycholic acid (3α ; 12α-dihydroxy-5β-cholan-24-oic acid) ; LCA ; lithocholic acid (3α-hydroxy-5β-cholan-24-oic acid) ; UCA ; ursocholic acid (3α ; 7β ; 12α-trihydroxy-5β-cholan-24-oic acid) ; CA ; cholic acid (3α ; 7α ; 12α-trihydroxy-5β-cholan-24-oic acid) ; CDCA ; chenodeoxycholic acid (3α ; 7α-dihydroxy-5β-cholan-24-oic acid) ; 12-keto-LCA ; 12-keto-lithocholic acid (3α-hydroxy-12-keto-5β-cholan-24-oic acid) ; 15β-hydroxy-DCA ; 3α ; 12α ; 15β-trihydroxy-5β-cholanoic acid ; 15β-hydroxy-12-oxo-LCA ; 3
- 刊名：Steroids
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：107
- 期：Complete
- 页码：20-29
- 全文大小：707 K
文摘
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Broad biocatalytic potency of filamentous fungi was revealed toward deoxycholic acid.
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Strains with 7α/β-, 15β-hydroxylase and 3α/12α-HSDH activities were discovered.
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Fusarium merismoides VKM F-2310 produced UCA with highest yield.
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Acremonium rutilum and Neurospora crassa strains exhibited high 15β-hydroxylase activity.
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