Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions
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- 作者：Adeola O. Adebisia ; Waseem Kaialyb ; Tariq Hussainc ; Hiba Al-Hamidid ; Ali Nokhodchie ; f ; Barbara R. Conwaya ; Kofi Asare-Addoa ; k.asare-addo@hud.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：GLU ; d-glucosamine hydrochloride ; DSC ; differential scanning calorimetry ; XRPD ; X-ray powder diffraction ; FTIR ; fourier transform infra-red ; BCS ; biopharmaceutical classification system ; CBZ ; carbamazepine ; PXM ; piroxicam ; NSAID ; non-steroidal anti-inflammatory drug ; DE ; dissolution efficiency ; MDT ; mean dissolution time ; MDR ; mean dissolution rate ; ATR ; attenuated total reflection ; PSD ; particle size distribution ; USP ; United States pharmacopoeia ; PM ; physical mixture
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：146
- 期：Complete
- 页码：841-851
- 全文大小：2056 K
文摘
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The spray drying process produced polymorphic transformations in (piroxicam) PXM.
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Glucosamine (GLU) improved dissolution in spray dried samples.
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GLU generally exhibited lower charge densities as compared to PXM.
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GLU improved the handling of PXM as it significantly reduced its charge in all the spray dried formulations.
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Technique could be used to determine appropriate formulations that improve handling.
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