Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma

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• 作者：Jin Hou¹ ; ² ; ¹¹ ; Li Lin³ ; ¹¹ ; Weiping Zhou⁴ ; ¹¹ ; Zhengxin Wang⁵ ; Guoshan Ding⁵ ; Qiongzhu Dong⁶ ; Lunxiu Qin⁶ ; Xiaobing Wu⁷ ; Yuanyuan Zheng¹ ; Yun Yang⁴ ; Wei Tian⁸ ; Qian Zhang¹ ; Chunmei Wang¹ ; Qinghua Zhang¹ ; Shi-Mei Zhuang⁹ ; Limin Zheng⁹ ; Anmin Liang¹⁰ ; Wenzhao Tao¹ ; Xuetao Cao¹ ; ² ; ^{caoxt@immunol.org}
• 刊名：Cancer Cell
• 出版年：2011
• 出版时间：15 February 2011
• 年：2011
• 卷：19
• 期：2
• 页码：232-243
• 全文大小：1456 K

文摘

Summary

The full scale of human miRNome in specific cell or tissue, especially in cancers, remains to be determined. An in-depth analysis of miRNomes in human normal liver, hepatitis liver, and hepatocellular carcinoma (HCC) was carried out in this study. We found nine miRNAs accounted for 88.2 % of the miRNome in human liver. The third most highly expressed miR-199a/b-3p is consistently decreased in HCC, and its decrement significantly correlates with poor survival of HCC patients. Moreover, miR-199a/b-3p can target tumor-promoting PAK4 to suppress HCC growth through inhibiting PAK4/Raf/MEK/ERK pathway both in vitro and in vivo. Our study provides miRNomes of human liver and HCC and contributes to better understanding of the important deregulated miRNAs in HCC and liver diseases.