A 4-week study of four 3-monochloropropane-1,2-diol diesters on lipid metabolism in C57BL/6J mice
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- 作者：Jing Lua ; Zhenning Wanga ; Mengrou Rena ; Guangxin Fenga ; Beining Yea ; Yi Wanga ; Baochen Fanga ; Xuming Dengb ; Shuang Guana ; gshuang1973@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：3-MCPD ; 3-monochloropropane-1 ; 2-diol ; CDP ; 3-MCPD palmitate diester ; CDS ; 3-MCPD stearate diester ; CDO ; 3-MCPD oleate diester ; CDL ; 3-MCPD linoleate diester ; NOAELs ; no-observed-adverse-effect levels
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：40
- 期：2
- 页码：453-458
- 全文大小：2141 K
文摘
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CDP, CDS, CDO and CDL significantly increased the serum TC, LDL-C levels at dose of 16.5 渭mol/kg/day respectively.
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CDP, CDS, CDO and CDL significantly increased liver TG, TC levels at dose of 16.5 渭mol/kg/day respectively.
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Oil red O staining confirmed CDP, CDS, CDO and CDL significantly increased fat accumulation in liver.