Iron-induced neuronal damage in a rat model of post-traumatic stress disorder
详细信息 查看全文
- 作者：Ming Zhaoa ; &dagger ; ; Zhibo Yua ; b ; &dagger ; ; Yang Zhanga ; Xueling Huangc ; Jingming Houd ; YanGang Zhaoe ; Wei Luoa ; Lin Chena ; Lan Oua ; Haitao Lia ; liihait@163.com" class="auth_mail" title="E-mail the corresponding author ; Jiqiang Zhange ; zhangjqtmmu@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer&rsquo ; s disease ; EPM ; elevated plus maze ; Fn ; ferritin ; HEPES ; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid ; ICP-OES ; inductively coupled plasma optical emission spectrometer ; IHC ; Immunohistochemistry ; PD ; Parkinson&rsquo ; s disease ; PTSD ; post-traumatic stress disorder ; SPS ; single prolonged stress ; TfR1 ; transferrin receptor 1
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：25 August 2016
- 年：2016
- 卷：330
- 期：Complete
- 页码：90-99
- 全文大小：1830 K
文摘
- •
SPS is a model which induced anxiety-like symptoms and increased GR in the hippocampus.
- •
Iron was increased in the hippocampus, prefrontal cortex and striatum after stress.
- •
Cells showed region-specific reaction to iron deposition.
- •
The neurons were injured in the areas of iron accumulation.