Plasma metabolic profiling analysis of cyclophosphamide-induced cardiotoxicity using metabolomics coupled with UPLC/Q⿿TOF⿿MS and ROC curve
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- 作者：Jia Yina ; Jiabin Xiea ; Xuejun Guoa ; Liang Jua ; Yubo Lia ; yaowufenxi001@sina.com" class="auth_mail" title="E-mail the corresponding author ; Yanjun Zhangb ; tianjin_tcm001@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cyclophosphamide ; Cardiotoxicity ; Metabolomics ; Multivariate data analysis ; Receiver operating characteristic curve
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：1033-1034
- 期：Complete
- 页码：428-435
- 全文大小：2060 K
文摘
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Potential biomarkers were figured out from three time-points by multivariate statistical and integration analyses.
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Two metabolic pathways related to cyclophosphamide were identified by metabolomics.
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ROC curve was used to validate the rationality of the biomarkers.
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Metabolomics technology provides a strategy for research on mechanism of CY⿿induced cardiotoxicity.