Polymorphism in a Sulfamethoxazole Derivative: Coexistence of Five Polymorphs in Methanol at Room Temperature

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• 作者：Muhammad Nawaz Tahir ; Zahid Shafiq ; Hazoor Ahmad Shad ; Zia-ur-Rehman ; Abdul Karim ; Muhammad Moazzam Naseer
• 刊名：Crystal Growth & Design
• 出版年：2015
• 出版时间：October 7, 2015
• 年：2015
• 卷：15
• 期：10
• 页码：4750-4755
• 全文大小：466K
• ISSN：1528-7505

文摘

A Schiff base derived from 2-hydroxy-1-naphthaldehyde and a well-known antibiotic sulfamethoxazole affords seven different conformational isomers which are present in five polymorphic forms in methanol solvent at room temperature. An exclusive preference for one of the four possible pairs of sulfonamide鈥搒ulfonimide and phenolimine鈥搆etoenamine tautomeric structures has been observed in the crystal structures of these polymorphs. This represents the first example of coexistence of five polymorphs in solution for any of the known compounds so far.