A Library of Thermoresponsive, Coacervate-Forming Biodegradable Polyesters

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• 作者：John P. Swanson ; Leanna R. Monteleone ; Fadi Haso ; Philip J. Costanzo ; Tianbo Liu ; Abraham Joy
• 刊名：Macromolecules
• 出版年：2015
• 出版时间：June 23, 2015
• 年：2015
• 卷：48
• 期：12
• 页码：3834-3842
• 全文大小：467K
• ISSN：1520-5835

文摘

We report on a new class of thermoresponsive biodegradable polyesters (TR-PE) inspired by polyacrylamides and elastin-like proteins (ELPs). The polyesters display reversible phase transition with tunable cloud point temperatures (T_cp) in aqueous solution as evidenced by UV鈥搗is spectroscopy, p>1p>H NMR, and DLS measurements. These polyesters form coacervate droplets above their lower critical solution temperature (LCST). The T_cp of the polyesters is influenced by the solutes such as urea, SDS, and NaCl. The T_cp of the copolymers shows a linear correlation with the composition of the polyesters indicating the ability to tune the phase change temperature. We also show that such thermoresponsive coacervates are capable of encapsulating small molecules such as Nile Red. Furthermore, the polyesters are hydrolytically degradable.