Electrophilic Activation of P-Alkynes in the Synthesis of P-Substituted and P-Centered Heterocycles

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• 作者：Akhil Gupta ; Bernard L. Flynn
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：May 20, 2016
• 年：2016
• 卷：81
• 期：10
• 页码：4012-4019
• 全文大小：384K
• 年卷期：0
• ISSN：1520-6904

文摘

Electrophilic activation of alkynylphosphine oxides and phosphonates provides a novel approach to the synthesis of P-substituted and P-centered heterocycles. Iodocyclization affords a heteroaryl iodide that can, among other things, be used in reiterative alkyne coupling and iodocyclization to give cyclic phosphonates and other cyclization reactions to give π-rich P-heterocycles.