Continuous-Flow Chemical Processing on a Microchip by Combining Microunit Operations and a Multiphase Flow Network

详细信息    查看全文

• 作者：Manabu Tokeshi ; Tomoko Minagawa ; Kenji Uchiyama ; Akihide Hibara ; Kiichi Sato ; Hideaki Hisamoto ; and Takehiko Kitamori
• 刊名：Analytical Chemistry
• 出版年：2002
• 出版时间：April 1, 2002
• 年：2002
• 卷：74
• 期：7
• 页码：1565 - 1571
• 全文大小：293K
• 年卷期：v.74,no.7(April 1, 2002)
• ISSN：1520-6882

文摘

A new design and construction methodology for integration of complicated chemical processing on a microchipwas proposed. This methodology, continuous-flow chemical processing (CFCP), is based on a combination ofmicrounit operations (MUOs) and a multiphase flownetwork. Chemical operations in microchannels, such asmixing, reaction, and extraction, were classified intoseveral MUOs. The complete procedure for Co(II) wetanalysis, including a chelating reaction, solvent extraction,and purification was decomposed into MUOs and reconstructed as CFCP on a microchip. Chemical reaction andmolecular transport were realized in and between continuous liquid flows in a multiphase flow network, suchas aqueous/aqueous, aqueous/organic, and aqueous/organic/aqueous flows. When the determination of Co(II) in an admixture of Cu(II) was carried out using thismethodology, the determination limit (2) was obtainedas 18 nM, and the absolute amount of Co chelatesdetected was 0.13 zmol, that is, 78 chelates. The sampleanalysis time was faster than that of a conventionalprocessing system. Moreover, troublesome operationssuch as phase separation and acid and alkali washing,all necessary for the conventional system, were simplified.The CFCP methodology proposed here can be applied tovarious on-chip applications.