Th
is paper summar
izes the recent act
iv
it
ies of the Chromosome-Centr
ic Human Proteome Project (C-HPP) consort
ium, wh
ich develops new technolog
ies to
ident
ify yet-to-be annotated prote
ins (termed 鈥渕
iss
ing prote
ins鈥?
in b
iolog
ical samples that lack suff
ic
ient exper
imental ev
idence at the prote
in level for conf
ident prote
in
ident
if
icat
ion. The C-HPP also a
ims to
ident
ify new prote
in forms that may be caused by genet
ic var
iab
il
ity, post-translat
ional mod
if
icat
ions, and alternat
ive spl
ic
ing. Proteogenom
ic data
integrat
ion forms the bas
is of the C-HPP鈥檚 act
iv
it
ies; therefore, we have summar
ized some of the key approaches and the
ir roles
in the project. We present new analyt
ical technolog
ies that
improve the chem
ical space and lower detect
ion l
im
its coupled to b
io
informat
ics tools and some publ
icly ava
ilable resources that can be used to
improve data analys
is or support the development of analyt
ical assays. Most of th
is paper鈥檚 content has been comp
iled from posters, sl
ides, and d
iscuss
ions presented
in the ser
ies of C-HPP workshops held dur
ing 2014. All data (posters, presentat
ions) used are ava
ilable at the C-HPP W
ik
i (
ing.rug.nl/" class="extLink">http://c-hpp.webhosting.rug.nl/) and in the Supporting Information.