Copper-Mediated Selective Cross-Coupling of 1,1-Dibromo-1-alkenes and Heteronucleophiles: Development of General Routes to Heterosubstituted Alkynes and Alkenes

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• 作者：K茅vin Jouvin ; Alexis Coste ; Alexandre Bayle ; Fr茅d茅ric Legrand ; Ganesan Karthikeyan ; Krishnaji Tadiparthi ; Gwilherm Evano
• 刊名：Organometallics
• 出版年：2012
• 出版时间：November 26, 2012
• 年：2012
• 卷：31
• 期：22
• 页码：7933-7947
• 全文大小：905K
• 年卷期：v.31,no.22(November 26, 2012)
• ISSN：1520-6041

文摘

Efficient and general procedures for the cross-coupling of 1,1-dibromoalkenes and N-, O-, and P-nucleophiles are reported. Fine-tuning of the reaction conditions allows for either site-selective, double, or alkynylative cross-coupling, therefore providing divergent and straightforward entries to numerous building blocks such as bromoenamides, ynamides, ketene N,N-acetals, bromoenol ethers, ynol ethers, ketene O,O-acetals, or vinylphosphonates and further expanding the copper catalysis toolbox with useful and versatile processes.