A Practical Synthesis of L-Valyl-pyrrolidine-(2R)-boronic Acid: Efficient Recycling of the Costly Chiral Auxiliary (+)-Pinanediol

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• 作者：Frank S. Gibson ; Ambarish K. Singh ; Maxime C. Soumeillant ; Percy S. Manchand ; Michael Humora ; and David R. Kronenthal
• 刊名：Organic Process Research & Development
• 出版年：2002
• 出版时间：November 2002
• 年：2002
• 卷：6
• 期：6
• 页码：814 - 816
• 全文大小：56K
• 年卷期：v.6,no.6(November 2002)
• ISSN：1520-586X

文摘

A practical synthesis of L-valyl-pyrrolidine-(2R)-boronic acid(1) is detailed. A previously disclosed synthesis of 1 (Snow, R.;Kelly, T. R.; Adams, J.; Coutts, S.; Perry, C. (BoehringerIngelheim Pharmaceuticals, Inc.). WO 93/10127, 1993) wassignificantly improved by developing an efficient process forrecycling the costly chiral auxiliary (+)- pinanediol.