A "Bottom-Up" Approach to Process Development: Application of Physicochemical Properties of Reaction Products toward the Development of Direct-Drop Processes

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• 作者：Chien-Kuang Chen and Ambarish K. Singh
• 刊名：Organic Process Research & Development
• 出版年：2001
• 出版时间：September 2001
• 年：2001
• 卷：5
• 期：5
• 页码：508 - 513
• 全文大小：93K
• 年卷期：v.5,no.5(September 2001)
• ISSN：1520-586X

文摘

The "bottom-up" approach to development of direct-dropprocesses is a powerful, yet simple, strategy that every processchemist should consider for the development of efficient, cost-effective, and environmentally friendly processes. This approachis aided by a "parallel crystallization" technique, which allowsfor rapid identification of multiple solvent systems for thecrystallization of the desired product using a minimal amountof material and solvent. This "bottom-up" approach is illustrated by several examples where the desired product iscrystallized directly from the reaction mixture.