Optical Detection of Ion-Channel-Induced Proton Transport in Supported Phospholipid Bilayers
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- 作者：Tsung-Han (Calvin) Yang ; Chanel K. Yee ; Meri L. Amweg ; Seema Singh ; Eric L. Kendall ; Andrew M. Dattelbaum ; Andrew P. Shreve ; C. Jeffrey Brinker ; Atul N. Parikh
- 刊名：Nano Letters
- 出版年：2007
- 出版时间：August 2007
- 年：2007
- 卷：7
- 期：8
- 页码：2446 - 2451
- 全文大小：922K
- 年卷期：v.7,no.8(August 2007)
- ISSN：1530-6992
文摘
The integration of ion-channel transport functions with responses derived from nanostructured and nanoporous silica mesophase materialsis demonstrated. Patterned thin-film mesophases consisting of alternating hydrophilic nanoporous regions and hydrophobic nanostructuredregions allow for spatially localized proton transport via selective dimerization of gramicidin in lipid bilayers formed on the hydrophilic regions.The adjoining hydrophobic mesostructure doped with a pH sensitive dye reports the transport. The ease of integrating functional membranesand reporters through the use of patterned mesophases should enable high throughput studies of membrane transport.