Structure and Biogenesis of Roussoellatide, a Dichlorinated Polyketide from the Marine-Derived Fungus Roussoella sp. DLM33

详细信息    查看全文

• 作者：Everton L. F. Ferreira ; David E. Williams ; Laura P. I贸ca ; Raquel P. Morais-Urano ; Mario F. C. Santos ; Brian O. Patrick ; Luciana M. Elias ; Simone P. Lira ; Antonio G. Ferreira ; Michel R. Z. Passarini ; Lara D. Sette ; Raymond J. Andersen ; Roberto G. S. Berlinck
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：November 6, 2015
• 年：2015
• 卷：17
• 期：21
• 页码：5152-5155
• 全文大小：326K
• ISSN：1523-7052

文摘

The structure of the fungal metabolite roussoellatide (1) has been established by spectroscopic and X-ray diffraction analyses. Results from feeding experiments with [1-¹³C]acetate, [2-¹³C]acetate, and [1,2-¹³C]acetate were consistent with a biosynthetic pathway to the unprecedented skeleton of 1 involving Favorskii rearrangements in separate pentaketides, subsequently joined via an intermolecular Diels鈥揂lder reaction.